Three new parasitic nematode worms

Immunity to Parasitic Worms

Helminth infection provides a unique challenge to the host immune system. Not only are helminths complex multicellular organisms, but they have intricate life cycles with multiple developmental stages, several of which may coexist in the infected host. In most cases, the host response to helminth infection is characterized by eosinophilia, increased serum immunoglobulin (Ig) E and IgG4, and mas...

The Challenge of Parasitic Worms

Parasitic worms and inflammatory diseases

The debate on whether infection precipitates or prevents autoimmunity remains a contentious one. Recently the suggestion that some unknown microbe can be at the origin of some chronic inflammatory diseases has been countered by accumulating evidence that decreasing infection rates might have an important role to play in the rising prevalence of autoimmune disorders. The 'Hygiene Hypothesis' was...

Hsp12.6 Expression Is Inducible by Host Immunity in Adult Worms of the Parasitic Nematode Nippostrongylus brasiliensis

Heat shock proteins (Hsp) are a family of stress-inducible molecular chaperones that play multiple roles in a wide variety of animals. However, the roles of Hsps in parasitic nematodes remain largely unknown. To elucidate the roles of Hsps in the survival and longevity of nematodes, particularly at the 2 most critical stages in their lifecycle, the infective-L3 stage and adult stage, which is s...

GTP-Cyclohydrolase function in parasitic nematode development

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